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KMID : 0604520150410010073
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 1 p.73 ~ p.83
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Effects of 1-tetradecanol and β-sitosterol Isolated from Dendropanax morbifera Lev. on Skin Whitening, Moisturizing and Preventing Hair Loss
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Lee Sun-Young
Choi Eun-Jin
Bae Dong-Hyuck
Lee Dong-Wook
Kim Sun-Oh
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Abstract
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Dendropanax morbifera Leveille (Araliaceae) is an endemic species growing in the south-western part of South Korea and has been used in folk medicine. However, the effects of Dendropanax morbifera Lev. on skin biology remain to be elucidated. In this study, we isolated 1-tetradecanol and β-sitosterol from the n-hexane fraction of Dendropanax mobifera Lev. and To investigate the whitening effect of the fraction, we tested the inhibition of tyrosinase activity of 1-tetradecanol. The results show that the inhibitory effect of the 1-tetradecanol was higher than water extract and n-hexane fraction. And 1-tetradecanol significantly reduced melanin contents of B16F10 cells compared to more than water extract and n-haxane fraction dose-dependantly without cell cytotoxicitiy (below 100μg/mL). We also investigated the skin moisturizing effect using HR-1 hairless mice. The transepidermal water loss (TEWL) in the 1-tetradecanol treated group was significantly smaller than that in the other groups. To investigate the effect of the preventing hair loss by β-sitosterol, we observed HR-1 hairless mice through periodic growth feature. The results suggest that hair loss of mice by β-sitosterol was delayed and it's hair density showed the highest. These data provide evidence that Dendropanax morbifera Lev. may be a potent candidate for the improvement of both skin whitening, moisturizing and alopecia from the point of cosmetic industry view.
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KEYWORD
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Dendropanax morbifera Leveille, 1-tetradecanol, β-sitosterol, whitening effect, moisturizing effect, hair loss
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